Mutual regulation between Hippo signaling and actin cytoskeleton
Protein & Cell
;
(12): 904-910, 2013.
Article
in English
| WPRIM
| ID: wpr-757544
ABSTRACT
Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphoproteins
/
Phosphorylation
/
Physiology
/
Transcription Factors
/
Actin Cytoskeleton
/
Nuclear Proteins
/
Signal Transduction
/
Trans-Activators
/
Gene Expression Regulation
/
Protein Serine-Threonine Kinases
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2013
Type:
Article
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