DNA methylome: Unveiling your biological age
Protein & Cell
;
(12): 723-725, 2013.
Article
in English
| WPRIM
| ID: wpr-757555
ABSTRACT
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Aging
/
Base Sequence
/
Chromatin
/
Genome, Human
/
Sequence Analysis, DNA
/
DNA Methylation
/
RNA, Untranslated
/
Epigenesis, Genetic
/
Genetics
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2013
Type:
Article
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