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Two Cases of Distal Renal Tubular Acidosis accompanied by Sjogren's Syndrome / 대한내과학회지
Korean Journal of Medicine ; : 248-252, 2016.
Article in Korean | WPRIM | ID: wpr-75760
ABSTRACT
Renal tubular acidosis (RTA) is a syndrome characterized by hyperchloremic metabolic acidosis and an inability to excrete highly acid urine, in which the impaired acid excretion is disproportional to the reduction in the glomerular filtration rate. Distal renal tubular acidosis (dRTA) is frequently associated with immune-mediated disease, including Sjogren's syndrome. Sjogren's syndrome is a systemic autoimmune disease that mainly affects exocrine glands, such as the lacrimal and salivary glands, resulting in xerophthalmia and xerostomia. Extraglandular manifestations are frequent and may include renal involvement. Recently, we experienced two cases of renal tubular acidosis in patients with Sjogren's syndrome. The first patient had lower extremity weakness and hypokalemia and the second had nephrocalcinosis. We discuss the frequency and pathogenesis of dRTA in Sjogren's syndrome.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Salivary Glands / Autoimmune Diseases / Acidosis / Acidosis, Renal Tubular / Xerostomia / Sjogren's Syndrome / Xerophthalmia / Lower Extremity / Exocrine Glands / Glomerular Filtration Rate Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Salivary Glands / Autoimmune Diseases / Acidosis / Acidosis, Renal Tubular / Xerostomia / Sjogren's Syndrome / Xerophthalmia / Lower Extremity / Exocrine Glands / Glomerular Filtration Rate Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2016 Type: Article