Recent progress in studies of factors that elicit pancreatic β-cell expansion
Protein & Cell
;
(12): 81-87, 2015.
Article
in English
| WPRIM
| ID: wpr-757612
ABSTRACT
The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat diabetes would be to enhance the ability of β-cells to increase the mass of functional β-cells. Consequently, much effort has been devoted to identify factors that can effectively induce β-cell expansion. This review focuses on recent reports on small molecules and protein factors that have been shown to promote β-cell expansion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Cell Communication
/
Cell Differentiation
/
Chemistry
/
Cell Proliferation
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
/
Genetics
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS