Proton transfer-mediated GPCR activation
Protein & Cell
;
(12): 12-17, 2015.
Article
in English
| WPRIM
| ID: wpr-757629
ABSTRACT
G-protein coupled receptors (GPCRs) play essential roles in signal transduction from the environment into the cell. While many structural features have been elucidated in great detail, a common functional mechanism on how the ligand-binding signal is converted into a conformational change on the cytoplasmic face resulting in subsequent activation of downstream effectors remain to be established. Based on available structural and functional data of the activation process in class-A GPCRs, we propose here that a change in protonation status, together with proton transfer via conserved structural elements located in the transmembrane region, are the key elements essential for signal transduction across the membrane.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protons
/
Signal Transduction
/
Chemistry
/
Amino Acid Motifs
/
Receptors, G-Protein-Coupled
/
Membrane Potentials
/
Membrane Proteins
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2015
Type:
Article
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