Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway
Protein & Cell
;
(12): 1073-1083, 2010.
Article
in English
| WPRIM
| ID: wpr-757678
ABSTRACT
The control of organ size growth is one of the most fundamental aspects of life. In the past two decades, a highly conserved Hippo signaling pathway has been identified as a key molecular mechanism for governing organ size regulation. In the middle of this pathway is a kinase cascade that negatively regulates the downstream component Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ)/Yorkie through phosphorylation. Phosphorylation of YAP/TAZ/Yorkie promotes its cytoplasmic localization, leads to cell apoptosis and restricts organ size overgrowth. When the Hippo pathway is inactivated, YAP/TAZ/Yorkie translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. In this review, we will focus on the structural and functional studies on the downstream transcription factor TEAD and its coactivator YAP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Phosphorylation
/
Physiology
/
Protein Binding
/
Nuclear Proteins
/
Signal Transduction
/
Trans-Activators
/
Protein Serine-Threonine Kinases
/
Apoptosis
/
Gene Expression Regulation, Developmental
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2010
Type:
Article
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