The role of BRCA1 in DNA damage response
Protein & Cell
;
(12): 117-123, 2010.
Article
in English
| WPRIM
| ID: wpr-757722
ABSTRACT
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Physiology
/
DNA Damage
/
Breast Neoplasms
/
Signal Transduction
/
Genes, Tumor Suppressor
/
Apoptosis
/
Genes, cdc
/
BRCA1 Protein
/
DNA Repair
Limits:
Female
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS