MAPK signaling in inflammation-associated cancer development
Protein & Cell
;
(12): 218-226, 2010.
Article
in English
| WPRIM
| ID: wpr-757734
ABSTRACT
Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases that sequentially phosphorylate one another. MAPKs transduce extracellular signals into a variety of cellular processes, such as cell proliferation, survival, death, and differentiation. Consistent with their essential cellular functions, MAPKs have been shown to play critical roles in embryonic development, adult tissue homeostasis and various pathologies. In this review, we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and, particularly, inflammation-associated cancer development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
MAP Kinase Signaling System
/
Extracellular Signal-Regulated MAP Kinases
/
JNK Mitogen-Activated Protein Kinases
/
P38 Mitogen-Activated Protein Kinases
/
Inflammation
/
Metabolism
/
Neoplasms
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2010
Type:
Article
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