Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
Protein & Cell
;
(12): 342-354, 2010.
Article
in English
| WPRIM
| ID: wpr-757756
ABSTRACT
Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Influenza A virus
/
Physiology
/
Therapeutics
/
Influenza Vaccines
/
Therapeutic Uses
/
Allergy and Immunology
/
Influenza, Human
/
Epidemics
/
Pandemics
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2010
Type:
Article
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