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NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer
Protein & Cell ; (12): 176-185, 2013.
Article in English | WPRIM | ID: wpr-757823
ABSTRACT
Although links between cancer and inflammation were firstly proposed in the nineteenth century, the molecular mechanism has not yet been clearly understood. Epidemiological studies have identified chronic infections and inflammation as major risk factors for various types of cancer. NF-κB transcription factors and the signaling pathways are central coordinators in innate and adaptive immune responses. STAT3 regulates the expression of a variety of genes in response to cellular stimuli, and thus plays a key role in cell growth and apoptosis. Recently, roles of NF-κB and STAT3 in colon, gastric and liver cancers have been extensively investigated. The activation and interaction between STAT3 and NF-κB play vital roles in control of the communication between cancer cells and inflammatory cells. NF-κB and STAT3 are two major factors controlling the ability of pre-neoplastic and malignant cells to resist apoptosis-based tumor-surveillance and regulating tumor angiogenesis and invasiveness. Understanding the molecular mechanisms of NF-κB and STAT3 cooperation in cancer will offer opportunities for the design of new chemo-preventive and chemotherapeutic approaches.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Signal Transduction / Cell Transformation, Neoplastic / Chemistry / NF-kappa B / Protein Structure, Tertiary / STAT3 Transcription Factor / Inflammation / Metabolism / Neoplasms Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: Protein & Cell Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Signal Transduction / Cell Transformation, Neoplastic / Chemistry / NF-kappa B / Protein Structure, Tertiary / STAT3 Transcription Factor / Inflammation / Metabolism / Neoplasms Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: Protein & Cell Year: 2013 Type: Article