Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism
Protein & Cell
;
(12): 83-85, 2013.
Article
in English
| WPRIM
| ID: wpr-757832
ABSTRACT
Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regenerative Medicine
/
Cellular Reprogramming
/
Induced Pluripotent Stem Cells
/
DNA Copy Number Variations
/
Metabolism
/
Mosaicism
Limits:
Humans
Language:
English
Journal:
Protein & Cell
Year:
2013
Type:
Article
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