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MCP-1-induced protein-1, an immune regulator
Protein & Cell ; (12): 903-910, 2012.
Article in English | WPRIM | ID: wpr-757849
ABSTRACT
MCP-1-induced protein-1 (MCPIP1) is a newly identified protein that is crucial to immune regulation. Mice lacking MCPIP1 gene suffer from severe immune disorders, and most of them cannot survive longer than 12 weeks. Considerable progress has been made in revealing the mechanism underlying the immune regulatory function of MCPIP1. MCPIP1 can act as an RNase to promote the mRNA degradation of some inflammatory cytokines, such as IL-6 and IL-1. Pre-microRNAs are also confirmed to be the substrate of MCPIP1 RNase. The structure of MCPIP1 N-terminal conserved domain shows a PilT N-terminus-like RNase structure, further supporting the notion that MCPIP1 has RNase activity. MCPIP1 can also deubiquitinate TNF receptor-associated factor family proteins, which are known to mediate immune and inflammatory responses. In this review, we summarize recent progress on the immune regulatory role of MCPIP1 and discuss the mechanisms underlying its function.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Ribonucleases / Transcription Factors / Molecular Sequence Data / Chemistry / Amino Acid Sequence / Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Ubiquitination / Immunity / Metabolism Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Protein & Cell Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ribonucleases / Transcription Factors / Molecular Sequence Data / Chemistry / Amino Acid Sequence / Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Ubiquitination / Immunity / Metabolism Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Protein & Cell Year: 2012 Type: Article