Detrimental Effect of the Peritoneal Injection of Papaverine for the Occlusive Mesenteric Ischemia in Rats

ABSTRACT

This study assessed the effect of vasodilator papaverine for the occlusive mesenteric ischemia in rats. Papaverine has been used for the treatment of nonocclusive mesenteric ischemia(NOMI), but its peripheral administration for the occlusive mesentric ischemia is known hazardous. This experiment was performed to confirm the detrimental effect of the peripheral administration of papaverine for the occlusive mesenteric ischemia in rats. The experimental animals were assigned to one of three groups. In the control group, laparotomy and thoracotomy were performed and blood samples were obtained from right atria of the rats. In one experimental group, after laparotomy and SMA ligation, papaverine was injected into the parietal peritoneum and the abdomens were closed. In the other experimental group, after laparotomy and SMA ligation, abdominal closures were performed. It is known that mesenteric infarction causes elevation of total serum creatine phosphokinase(CPK) and each of its three isoenzymes and it is also known that CPK BB isoenzyme is the earliest isoenzyme of the three. In this experiment, although there were no statistical significances, total CPK and all its three isoenzymes showed higher levels after 1hour in SMA ligation with papaverine treated group than those in SMA ligation alone group. And especially CPK BB isoenzyme revealed higher levels after 30 minutes in SMA ligation with papaverine treated group than that in SMA ligation alone. Therefore it is supposed that peritoneal injection of vasodilator papaverine might be hazardous for the occlusive mesenteric ischemia in rats.