Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences
Journal of Veterinary Science
;
: e1-2019.
Article
in English
| WPRIM
| ID: wpr-758906
ABSTRACT
The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Camelus
/
Zoonoses
/
Open Reading Frames
/
Coronavirus Infections
/
Evolution, Molecular
/
Clinical Coding
/
Middle East Respiratory Syndrome Coronavirus
/
Immunity, Innate
/
Middle East
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Veterinary Science
Year:
2019
Type:
Article
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