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Histopathological and microbiological findings in buffalo chronic mastitis: evidence of tertiary lymphoid structures
Journal of Veterinary Science ; : e28-2019.
Article in English | WPRIM | ID: wpr-758910
ABSTRACT
Buffalo mastitis is an important economic problem in southern Italy, causing qualitative/quantitative alterations in milk and resulting in economic losses due to the sub-clinical course and chronic evolution. We investigated 50 udders of slaughtered buffaloes and subjected them to effectual microbiological screening to evaluate macro and microscopic mammary gland changes, immune-characterize the cell infiltrates, and compare the degree of tissue inflammation with somatic cell counts. Numerous Gram-positive and Gram-negative bacteria were isolated from all samples, majority of which were environmental mastitis pathogens. Histological features referable to chronic mastitis were observed in 92% udders. Lymphocytes, plasma cells and macrophages were found to evolve into aggregates in 48% udders, which often organized to form tertiary lymphoid structures (TLSs). A predominance of interstitial CD8+ over CD4+ lymphocytes and, in TLSs, scattered CD8+ lymphocytes in the mantle cells and CD79+ lymphocytes in germinal centers, were evidenced. Environmental pathogens are known to persist and cause chronic inflammatory changes in buffaloes, where CD8+ lymphocytes play an important role by controlling the local immune response. Moreover, the TLSs evidenced here for the first time in buffalo mastitis, could play a role in maintaining immune responses against persistent antigens, thereby contributing in determining the chronic course of mastitis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma Cells / Buffaloes / Lymphocytes / Cell Count / Mass Screening / Germinal Center / Mammary Glands, Human / Milk / Gram-Negative Bacteria / Inflammation Type of study: Diagnostic study / Prognostic study / Qualitative research / Screening study Limits: Animals Country/Region as subject: Europa Language: English Journal: Journal of Veterinary Science Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma Cells / Buffaloes / Lymphocytes / Cell Count / Mass Screening / Germinal Center / Mammary Glands, Human / Milk / Gram-Negative Bacteria / Inflammation Type of study: Diagnostic study / Prognostic study / Qualitative research / Screening study Limits: Animals Country/Region as subject: Europa Language: English Journal: Journal of Veterinary Science Year: 2019 Type: Article