Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis
Journal of Veterinary Science
;
: e53-2019.
Article
in English
| WPRIM
| ID: wpr-758938
ABSTRACT
YKL-40, a secreted glycoprotein, may serve as an autoantigen, which mediates multiple inflammatory diseases and cancers. A high YKL-40 serum level is correlated with metastasis and poor survival in a variety of human cancers. However, the role of YKL-40 in dogs is still under evaluation. Herein, we examined the associations between plasma YKL-40 level and YKL-40 autoantibody (YAA) titers with malignancy and prognosis in canine cancer. Plasma levels of YKL-40 in healthy dogs (n = 20) and in dogs (n = 82) with cancer were evaluated using enzyme-linked immunosorbent assay. Our results indicated that plasma YKL-40 levels were significantly higher (p 180 pg/mL) than in the low YKL-40 group (< 180 pg/mL). The results imply that plasma YKL-40 levels might have the potential to be developed as a marker of malignancy progression and prognosis in canine cancers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Prognosis
/
Recurrence
/
Autoantibodies
/
Autoantigens
/
Enzyme-Linked Immunosorbent Assay
/
Glycoproteins
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Veterinary Science
Year:
2019
Type:
Article
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