Rivaroxaban and Acetylsalicylic Acid for Prevention of Venous Thromboembolism Following Total Knee Arthroplasty in Korean Patients
The Journal of Korean Knee Society
;
: 247-254, 2018.
Article
in English
| WPRIM
| ID: wpr-759329
ABSTRACT
PURPOSE:
To investigate the incidence of venous thromboembolism (VTE) after total knee arthroplasty (TKA) with chemoprophylaxis using acetylsalicylic acid (AA) or rivaroxaban in Korean patients. MATERIALS ANDMETHODS:
Between May 2011 and November 2013, 268 TKA patients (330 cases) were randomly allocated to 3 groups (group A subcutaneous injection of 5,000 IU low-molecular-weight heparin for 2 days followed by oral administration of 100 mg AA for 5 days; group X7 oral administration of 10mg rivaroxaban for 7 days; and group X10 oral administration of 10 mg rivaroxaban for 10 days). Multidetector-row computed tomography (MDCT) was performed at 10 days and 3 months postoperatively to evaluate VTE changes.RESULTS:
The VTE incidence was 38.2%, 20.0%, and 10.0% in groups A, X7, and X10, respectively (p < 0.001). Pulmonary embolism (PE) was identified in 19.1%, 10.0%, and 2.7% in groups A, X7, and X10, respectively (p < 0.001). Proximal or symptomatic deep vein thrombosis (DVT) occurred primarily in group A, but the incidence was not significantly different among groups. On follow-up MDCT, PE was resolved completely with treatment in 29/30 (96.7%), and so was asymptomatic distal DVT in 24/27 (88.8%) without treatment.CONCLUSIONS:
Rivaroxaban had a lower incidence of overall VTE than AA, but no difference was observed in symptomatic VTE. The 10-day course of rivaroxaban had a lower incidence of overall VTE than the 7-day course.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthroplasty
/
Pulmonary Embolism
/
Aspirin
/
Incidence
/
Administration, Oral
/
Follow-Up Studies
/
Heparin, Low-Molecular-Weight
/
Chemoprevention
/
Arthroplasty, Replacement, Knee
/
Venous Thrombosis
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
The Journal of Korean Knee Society
Year:
2018
Type:
Article
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