Intra-Articular Injection of Bone Marrow-Derived Mesenchymal Stem Cells Leading to Better Clinical Outcomes without Difference in MRI Outcomes from Baseline in Patients with Knee Osteoarthritis
The Journal of Korean Knee Society
;
: 206-214, 2018.
Article
in English
| WPRIM
| ID: wpr-759334
ABSTRACT
PURPOSE:
Bone marrow (BM) is frequently used as a source of mesenchymal stem cells (MSCs) because they have a high potential for differentiation. However, it is unclear whether BM-derived MSCs lead to better clinical and magnetic resonance imaging (MRI) outcomes postoperatively. MATERIALS ANDMETHODS:
This meta-analysis compared the clinical and MRI outcomes in patients with knee osteoarthritis (OA) treated with BM-derived MSCs. Eight studies comparing the clinical and MRI outcomes assessed with various measurement tools in patients with knee OA treated with BM-derived MSCs were included.RESULTS:
The range of motion (95% confidence interval [CI], −13.05 to 4.24; p=0.32) and MRI outcomes (95% CI, −0.16 to 1.40; p=0.12) did not differ significantly between the baseline and final follow-up. In contrast, pain (95% CI, 0.89 to 1.87; p < 0.001) and functional outcomes (95% CI, 0.70 to 2.07; p < 0.001) were significantly improved at the final follow-up when compared to the baseline.CONCLUSIONS:
This meta-analysis found no significant difference in the tested range of motion and MRI outcomes between the baseline and the final follow-up in patients treated with BM-derived MSCs, whereas significant functional improvement and pain relief were noted when compared with the baseline. Thus, BM-derived MSCs appear to be a viable alternative for patients with knee OA, although long-term and high-quality randomized controlled trials are needed to confirm the clinical benefits.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Bone Marrow
/
Magnetic Resonance Imaging
/
Follow-Up Studies
/
Range of Motion, Articular
/
Osteoarthritis, Knee
/
Mesenchymal Stem Cells
/
Injections, Intra-Articular
/
Knee
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
The Journal of Korean Knee Society
Year:
2018
Type:
Article
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