Significance of Differential Characteristics in Infantile Kawasaki Disease
Korean Circulation Journal
;
: 755-765, 2019.
Article
in English
| WPRIM
| ID: wpr-759456
ABSTRACT
BACKGROUND AND OBJECTIVES:
Immunological variability in Kawasaki disease (KD) shows age-specific differences; however, specific differences in laboratory values have not been compared between infants and non-infants with KD. We compared age-adjusted Z-values (Z) of white and red blood cells in infants with KD with those in non-infants with KD.METHODS:
This study retrospectively investigated 192 infants and 667 non-infants recruited between 2003 and 2015 at the Korea University Hospital. Laboratory values for infants with KD and non-infants with KD were analyzed and age-unadjusted raw values (R) and age-adjusted Z for blood cells counts were determined.RESULTS:
Z in infants with KD during pre-intravenous immunoglobulin (IVIG), post-IVIG, and chronic phases showed increased lymphopenia and eosinophilia, low neutrophillymphocyte and neutrophileosinophil ratios, worse anemia, increased thrombocytosis, and reduced erythrocyte sedimentation rates compared with those in non-infants with KD. The optimal cut-off value for pre-IVIG Z-hemoglobin for prediction of KD in all patients was 40 mg/L (AUC, 0.811; sensitivity/specificity, 0.712/0.700; p=0.04).CONCLUSIONS:
Laboratory characteristics enable differentiation between infants and non-infants with KD and contribute to a better understanding of changes in blood cell counts. Infants with incomplete KD can be more easily differentiated from infants with simple febrile illness using pre-IVIG Z-hemoglobin and pre-IVIG CRP values.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thrombocytosis
/
Blood Cell Count
/
Blood Cells
/
Blood Sedimentation
/
C-Reactive Protein
/
Immunoglobulins
/
Retrospective Studies
/
Eosinophilia
/
Erythrocytes
/
Anemia
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Infant
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Circulation Journal
Year:
2019
Type:
Article
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