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Visual Field Defect after Taking Atorvastatin/Ezetimibe, a Case Study
Korean Journal of Clinical Pharmacy ; : 133-137, 2019.
Article in Korean | WPRIM | ID: wpr-759613
ABSTRACT
Atorvastatin is one of the most widely prescribed medications for dyslipidemia treatment. In Korea, post combined therapy with ezetimibe, a 73-year-old woman was reported by a community pharmacy to have experienced visual field defect, which recovered after drug discontinuation. She had never experienced this symptom before, and several studies have reported an association between use of statins and visual disorders such as blurred vision, diplopia, and cataract. Blockage of cholesterol accumulation, oxidative stress, or myopathy is expected to be a cause of this symptom. Naranjo scale, Korean causality assessment algorithm (Ver.2), and World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria were the three tools used to determine causality between the visual disorder and atorvastatin. The results represent ‘probable’, ‘certain’, and ‘probable/likely’ causality, respectively. Our results, in combination with a review of literature, indicate that ocular adverse effects are highly likely related to atorvastatin.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacies / Vision Disorders / Cataract / Visual Fields / Cholesterol / Global Health / Oxidative Stress / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Diplopia / Drug-Related Side Effects and Adverse Reactions Limits: Aged / Female / Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Clinical Pharmacy Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacies / Vision Disorders / Cataract / Visual Fields / Cholesterol / Global Health / Oxidative Stress / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Diplopia / Drug-Related Side Effects and Adverse Reactions Limits: Aged / Female / Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Clinical Pharmacy Year: 2019 Type: Article