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A Case of Immunoglobulin A Pemphigus: Intraepidermal Neutrophilic Dermatosis Type / 대한피부과학회지
Korean Journal of Dermatology ; : 492-495, 2019.
Article in English | WPRIM | ID: wpr-759781
ABSTRACT
Immunoglobulin A (IgA) pemphigus is a rare variant of an autoimmune bullous disease with IgA antibodies. IgA pemphigus is divided into 2 major subtypes the subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic (IEN) dermatosis type. We documented a case of an 18-year-old woman with recurrent generalized blisters and pustules that were especially severe in the intertriginous areas. Some half-and-half blisters and coalesced pustules in an annular pattern with crusts were simultaneously observed. A biopsy specimen from one of the half-and-half blister lesions showed intraepidermal separation with multiple neutrophils. Direct immunofluorescence staining revealed lace-like intercellular deposition of IgA in the entire epidermis. IgA antibody deposits were also observed in the patient's serum. The eruptions cleared with systemic steroids and colchicine 0.6 mg for 1 week, and the patient remained in partial remission at the 8-month follow-up. Herein, we report a case of IEN-type IgA pemphigus, clinically mimicking SPD with half-and-half blisters.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin Diseases / Steroids / Biopsy / Immunoglobulin A / Immunoglobulins / Colchicine / Follow-Up Studies / Skin Diseases, Vesiculobullous / Blister / Pemphigus Type of study: Observational study / Prognostic study Limits: Adolescent / Female / Humans Language: English Journal: Korean Journal of Dermatology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin Diseases / Steroids / Biopsy / Immunoglobulin A / Immunoglobulins / Colchicine / Follow-Up Studies / Skin Diseases, Vesiculobullous / Blister / Pemphigus Type of study: Observational study / Prognostic study Limits: Adolescent / Female / Humans Language: English Journal: Korean Journal of Dermatology Year: 2019 Type: Article