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Frequency and Severity of Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with a Sulfonylurea-Based Regimen at University-Affiliated Hospitals in Korea: The Naturalistic Evaluation of Hypoglycemic Events in Diabetic Subjects Study / 가정의학회지
Korean Journal of Family Medicine ; : 212-219, 2019.
Article in English | WPRIM | ID: wpr-759817
ABSTRACT

BACKGROUND:

We assessed the frequency and severity of hypoglycemia in type 2 diabetes mellitus patients treated with sulfonylurea monotherapy or sulfonylurea+metformin.

METHODS:

We conducted a retrospective, observational, cross-sectional study in 2011 and 2012 including patients with type 2 diabetes mellitus aged ≥30 years who were treated with ≥6 months of sulfonylurea monotherapy or sulfonylurea+metformin at 20 university-affiliated hospitals in Korea. At enrollment, glycated hemoglobin (HbA1c) was assessed; participants completed self-reported questionnaires describing hypoglycemia incidents over the past 6 months. A review of medical records up to 12 months before enrollment provided data on demographics, disease history, comorbidities, laboratory results, and drug usage.

RESULTS:

Of 726 enrolled patients, 719 were included (55.6% male); 31.7% and 68.3% were on sulfonylurea monotherapy and sulfonylurea+metformin, respectively. Mean±standard deviation age was 65.9±10.0 years; mean HbA1c level was 7.0%±1.0%; 77.8% of patients had hypertension (89.4% used antihypertensive medication); 60.5% had lipid disorders (72.5% used lipid-lowering medication); and 52.0% had one or more micro- or macrovascular diseases. Among patients with A1c measurement (n=717), 56.4% achieved therapeutic goals (HbA1c <7.0%); 42.4% (305/719) experienced hypoglycemia within 6 months of enrollment; and 38.8%, 12.9%, 12.7%, and 3.9% of patients experienced mild, moderate, severe, and very severe hypoglycemia symptoms, respectively. Several reported hypoglycemia frequency as 1–2 times over the last 6 months. The mean number of very severe hypoglycemia episodes was 3.5±5.5.

CONCLUSION:

Among type 2 diabetes mellitus patients treated with sulfonylurea-based regimens, glycemic levels were relatively well controlled but hypoglycemia remained a prevalent side effect.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Glycated Hemoglobin / Comorbidity / Demography / Medical Records / Cross-Sectional Studies / Retrospective Studies / Diabetes Mellitus, Type 2 / Hypertension / Hypoglycemia / Korea Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Korean Journal of Family Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Glycated Hemoglobin / Comorbidity / Demography / Medical Records / Cross-Sectional Studies / Retrospective Studies / Diabetes Mellitus, Type 2 / Hypertension / Hypoglycemia / Korea Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Korean Journal of Family Medicine Year: 2019 Type: Article