Epileptic Seizure Due to Disulfiram Treatment / 가정의학회지
Korean Journal of Family Medicine
;
: 406-408, 2019.
Article
in English
| WPRIM
| ID: wpr-759830
ABSTRACT
Disulfiram has been used for the treatment of alcohol dependence for nearly 65 years and is approved by the Food and Drug Administration. It causes negative reinforcement by accumulating toxic acetaldehyde due to irreversible inhibition of aldehyde dehydrogenase. Disulfiram has very few side effects when taken without alcohol. Epileptic seizure induction is a rare side effect in therapeutic doses, and its mechanism is unknown. We present a patient with a single epileptic seizure which was thought to be due to disulfiram used in the treatment of alcohol dependence. We did not find it ethical to administer disulfiram again because the patient discontinued alcohol use and was afraid of epileptic seizures.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reinforcement, Psychology
/
United States Food and Drug Administration
/
Disulfiram
/
Alcoholism
/
Aldehyde Dehydrogenase
/
Epilepsy
/
Acetaldehyde
Limits:
Humans
Language:
English
Journal:
Korean Journal of Family Medicine
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS