Effects of simvastatin on coagulation parameters in dyslipidemia patients
Journal of Medical Research
;
: 23-29, 2008.
Article
in Vietnamese
| WPRIM
| ID: wpr-760
ABSTRACT
Background:
Statin and its derivate (simvastatin, autorvastatin, etc...) are used for dyslipidemia treatment and preventing thrombose. However, the mechanism of the antithrombotic action is still being studied.Objectives:
(1) To study coagulation parameters in dyslipidemia. (2) To evaluate the effects of simvastatin on coagulation parameters in dyslipidemia patients. Subject andMethod:
A prospective study was carried out in a sample of 22 patients with primary hypercholesterolemia (type IIa), who were treated with simvastatin 20mg/d for 1 month. The lipid parameters (cholesterol, triglycerid, HDL, LDL) and coagulation parameters (PT, APTT, fibrinogen, factor II, V, VII, X, VIII, IX, XI) were compared between pre and post therapy, and to the control group (59 healthy people).Results:
Most of coagulation parameter values (except factor VIII and X) of the pre treatment group were significantly change towards hypercoagulation (p<0.05%) when compared to the control group. After treatment, PT rate, APTT, APTT rate, fibrinogen, factor VII and IX were significantly changed towards coagulation when compared to pre treatment (p<0.05%). The plasma coagulation and lipid parameters of more than 50% of the hypercholesterolemia patients returned to normal values after treatment.Conclusions:
Simvastatin therapy on dyslipidemia patients can reduce not only the level of serum lipid, but also coagulation, and proved its effectiveness in the prevention of thrombosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Simvastatin
/
Dyslipidemias
Type of study:
Observational study
Language:
Vietnamese
Journal:
Journal of Medical Research
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS