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The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia / 소아과
Korean Journal of Pediatrics ; : 173-178, 2019.
Article in English | WPRIM | ID: wpr-760202
ABSTRACT

PURPOSE:

To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA).

METHODS:

We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L.

RESULTS:

A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from 24.43±1.64 to 28.21±1.72 pg/L (P=0.000). Mean Ret-He level in group 2 changed from 24.31±1.42 to 27.03±2.14 pg/L (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05).

CONCLUSION:

Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Reticulocytes / Anemia, Iron-Deficiency / Absorption / Limosilactobacillus reuteri / Non-Randomized Controlled Trials as Topic / Indonesia / Anemia / Iron / Lactobacillus Type of study: Controlled clinical trial Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Korean Journal of Pediatrics Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Reticulocytes / Anemia, Iron-Deficiency / Absorption / Limosilactobacillus reuteri / Non-Randomized Controlled Trials as Topic / Indonesia / Anemia / Iron / Lactobacillus Type of study: Controlled clinical trial Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Korean Journal of Pediatrics Year: 2019 Type: Article