Acute Monoblastic Leukemia with t(11;17)(q23;q21): Fusion of the KMT2A(MLL) and MLLT6(AF17) Genes
Laboratory Medicine Online
;
: 258-262, 2019.
Article
in English
| WPRIM
| ID: wpr-760507
ABSTRACT
The KMT2A (formerly MLL) gene is associated with at least 10% of all cases of acute leukemia. More than 80 translocation partner genes of KMT2A have been discovered to date, six of which have been identified on the long arm of chromosome 17. Among these, the MLLT6 (formerly AF17) gene is located at 17q12 and fuses with the KMT2A gene in rare cases of acute leukemia. We report here a case of AML with a KMT2A/MLLT6 fusion that was confirmed using molecular genetic methods. According to a literature review, this is the first reported case of AML with a KMT2A/MLLT6 fusion in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arm
/
Chromosomes, Human, Pair 17
/
Leukemia
/
Leukemia, Monocytic, Acute
/
Korea
/
Molecular Biology
Country/Region as subject:
Asia
Language:
English
Journal:
Laboratory Medicine Online
Year:
2019
Type:
Article
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