Result Patterns and Characteristics of HBeAg and HBV DNA in Patients with Chronic Hepatitis B
Laboratory Medicine Online
;
: 210-217, 2019.
Article
in English
| WPRIM
| ID: wpr-760516
ABSTRACT
BACKGROUND:
Discrepancies in the results between hepatitis B e-antigen (HBeAg) and hepatitis B virus (HBV) DNA levels pose difficulties in the management of chronic hepatitis B (CHB). This study aims to better understand the different phases of CHB and to detect additional meaningful parameters for CHB patients.METHODS:
We collected datasets of HBeAg and HBV DNA levels measured during 2016 and the follow-up results for CHB patients for past 3 years. We analyzed the collected data by applying the definitions of CHB clinical phase and compared the results of semi-quantitative and quantitative HBeAg assays.RESULTS:
About 55% of 2,291 result pairs from CHB patients showed qualitative agreement between HBeAg and HBV DNA results. HBeAg (−) CHB was reported in 16.49%, while hepatitis B surface antigen (HBsAg) loss occurred in 0.18% among 1,146 patients annually. HBeAg reversion occurred in 2.74% of 839 patients that experienced HBeAg seroconversion. Patients with HBeAg (+) and HBV DNA (−) showed statistically significant differences in the levels and percentage abnormality of alanine aminotransferase (ALT) based on whether HBV DNA was ‘Target not detected’ or ‘Detected,CONCLUSIONS:
This study reveals clinically important result patterns during the different phases of CHB. ALT level and percentage abnormality were significantly different based on HBV DNA status in HBeAg (+) and HBV DNA (−) patients. We suggest that clinical laboratories should report ‘HBV DNA (−)’ separately as ‘Target not detected’ and ‘Detected,
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
DNA, Viral
/
Hepatitis B virus
/
Follow-Up Studies
/
Hepatitis B, Chronic
/
Alanine Transaminase
/
Dataset
/
Seroconversion
/
Hepatitis B
/
Hepatitis B e Antigens
Type of study:
Observational study
/
Prognostic study
/
Qualitative research
Limits:
Humans
Language:
English
Journal:
Laboratory Medicine Online
Year:
2019
Type:
Article
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Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
DNA, Viral
/
Hepatitis B virus
/
Follow-Up Studies
/
Hepatitis B, Chronic
/
Alanine Transaminase
/
Dataset
/
Seroconversion
/
Hepatitis B
/
Hepatitis B e Antigens
Type of study:
Observational study
/
Prognostic study
/
Qualitative research
Limits:
Humans
Language:
English
Journal:
Laboratory Medicine Online
Year:
2019
Type:
Article