Identification of a Novel Function of Extract of Gingko biloba (EGb 761®) as a Regulator of PYY Secretion and FFA4 Activation
Natural Product Sciences
;
: 165-171, 2019.
Article
in English
| WPRIM
| ID: wpr-760548
ABSTRACT
Although the functions of a standardized extract of Gingko biloba leaves (EGb 761®) has been reported with regard to neurobiological properties, no attention has been paid to the impact of EGb 761® on the neuronal regulation of energy homeostasis. To evaluate the hypothesis that EGb 761® affect the secretion of peptide tyrosine tyrosine (PYY) and the activation of free fatty acid receptor 4 (FFA4), which are involved in the neuronal circuitries that control energy homeostasis by inducing the transfer of information about the influx of energy to the brain, we examined whether EGb 761® can stimulate PYY secretion in the enteroendocrine NCI-H716 cells and if EGb 761® can activate FFA4 in FFA4-expressing cells. In NCI-H716 cells, EGb 761® stimulated PYY secretion and the EGb 761®-induced PYY secretion was involved in the increase in intracellular Ca2+ concentration and the activation of FFA4. Furthermore, in FFA4-expressing cells, EGb 761® activated FFA4. These results suggest that EGb 761® may affect the control of energy homeostasis via the regulation of PYY secretion and FFA4 activation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tyrosine
/
Brain
/
Ginkgo biloba
/
Homeostasis
/
Neurons
Type of study:
Diagnostic study
Language:
English
Journal:
Natural Product Sciences
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS