Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity
Natural Product Sciences
;
: 115-121, 2019.
Article
in English
| WPRIM
| ID: wpr-760555
ABSTRACT
Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl(1→6)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxypregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-15β-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at 100 µM. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and π-π stacking interactions which could explain the compound potency to inhibit AChE and BChE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acetylcholinesterase
/
In Vitro Techniques
/
Butyrylcholinesterase
/
Cholinesterases
/
Neurodegenerative Diseases
/
Alzheimer Disease
/
Hydrogen
Language:
English
Journal:
Natural Product Sciences
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS