Phytochemical Constituents of the Root Bark from Morus alba and Their Il-6 Inhibitory Activity
Natural Product Sciences
;
: 268-274, 2019.
Article
in English
| WPRIM
| ID: wpr-760561
ABSTRACT
Morus alba L., known as white mulberry, is a medicinal plant belongs to family Moraceae. It has long been used commonly in Ayurvedic for the treatment of lung-heat, cough, asthma, hematemesis, dropsy and hypertension. In the present study, seven prenylated flavonoids, along with four benzofuran compounds were isolated by means of repeated column chromatography. The structures of the known compounds were identified as kuwanon G (1), kuwanon E (2), kuwanon T (3), morusin (4), sanggenon A (5), sanggenon M (6), sanggenol A (7), moracin R (8), mulberofuran G (9), mulberofuran A (10) and mulberofuran B (11), by comparing their spectroscopic data with those reported in the literature. For these isolates, containing trace compounds, the inhibitory activity against IL-6 production in TNF-α stimulated MG-63 cells was examined. All isolated compounds (1
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Asthma
/
Flavonoids
/
Hematemesis
/
Chromatography
/
Interleukin-6
/
Cough
/
Moraceae
/
Morus
/
Edema
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Natural Product Sciences
Year:
2019
Type:
Article
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