Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp
Natural Product Sciences
; : 228-232, 2019.
Article
in En
| WPRIM
| ID: wpr-760568
Responsible library:
WPRO
ABSTRACT
Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3) , 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with IC₅₀ from 0.5 to 25 µmol/mL.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Artemia
/
Hep G2 Cells
/
Fungi
/
Griseofulvin
Language:
En
Journal:
Natural Product Sciences
Year:
2019
Type:
Article