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Effects of Early Phosphorus Intake on Respiratory Distress in Extremely Low-Birth-Weight Infants
Neonatal Medicine ; : 155-161, 2019.
Article in Korean | WPRIM | ID: wpr-760586
ABSTRACT

PURPOSE:

This study was aimed to investigate the effect of early phosphorus intake on respiratory distress in extremely low-birth-weight infants (ELBWIs) with a high incidence of hypophosphatemia.

METHODS:

We performed a retrospective study to target 164 ELBWIs admitted to the neonatal intensive care unit in Seoul National University Children's Hospital. Birth characteristics, nutritional intake, and electrolyte levels during the first week were investigated as predictors that would affect the clinical outcomes. The correlations among invasive ventilation at postnatal age of 2 weeks, moderate-to-severe bronchopulmonary dysplasia (BPD), and phosphorous intake were analyzed.

RESULTS:

Hypophosphatemia (phosphorus level <4 mg/dL) was observed in 72.0% of the subjects. The rates of invasive ventilation (P=0.001) and moderate-to-severe BPD (P=0.005) were significantly lower in the high phosphorus intake group (≥0.7 mM/kg/day) than in the low phosphorus intake group (<0.7 mM/kg/day). Phosphorus intake during the first week was a significant factor affecting invasive ventilation at 2 weeks of age (adjusted odds ratio [OR], 8.212; 95% confidence interval [CI], 2.256 to 28.896; P=0.001) and moderate-to-severe BPD (adjusted OR, 3.402; 95% CI, 1.274 to 9.084; P=0.015).

CONCLUSION:

Early insufficient phosphorus intake confers a significantly higher risk with invasive ventilation at 2 weeks of age and moderate-to-severe BPD. Therefore, early sufficient phosphorus supply may improve respiratory outcomes in ELBWIs.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorus / Ventilation / Bronchopulmonary Dysplasia / Infant, Low Birth Weight / Intensive Care, Neonatal / Odds Ratio / Incidence / Retrospective Studies / Hypophosphatemia / Parturition Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans / Infant, Newborn Country/Region as subject: Asia Language: Korean Journal: Neonatal Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorus / Ventilation / Bronchopulmonary Dysplasia / Infant, Low Birth Weight / Intensive Care, Neonatal / Odds Ratio / Incidence / Retrospective Studies / Hypophosphatemia / Parturition Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans / Infant, Newborn Country/Region as subject: Asia Language: Korean Journal: Neonatal Medicine Year: 2019 Type: Article