Pituitary magnetic resonance imaging abnormalities in young female patients with hypogonadotropic hypogonadism
Obstetrics & Gynecology Science
;
: 249-257, 2019.
Article
in English
| WPRIM
| ID: wpr-760650
ABSTRACT
OBJECTIVE:
To elucidate the association between clinical and laboratory characteristics and pituitary magnetic resonance imaging (MRI) abnormalities in young female patients with hypogonadotropic hypogonadism (HH).METHODS:
We retrospectively investigated a series of 74 female patients (age range, 14–42 years) with normoprolactinemic HH who underwent pituitary MRI. Pubertal milestones and hormonal features of patients with small pituitary glands (PGs) and space-occupying lesions were compared with those of patients with normal PGs.RESULTS:
The overall frequency of abnormal PGs was 35.1%, with space-occupying lesions observed in 8 patients (10.8%), and small PG observed in 18 patients (24.3%). The mean serum gonadotropin level was not different between patients with and without pituitary MRI abnormalities (P>0.05). Space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. The frequency of space-occupying lesions was higher in patients with interrupted puberty (25.0%) than in patients who did not go through puberty (4.8%) or had a normal puberty (9.8%), but were not statistically significant (P>0.05). Small PG was associated with low gonadotropin levels and type of amenorrhea (P<0.05).CONCLUSION:
Clinically significant space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. However, the frequency of space-occupying lesions was higher in patients with interrupted puberty than in patients who did not go through puberty or who with normal puberty.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Gland
/
Puberty, Delayed
/
Magnetic Resonance Imaging
/
Retrospective Studies
/
Puberty
/
Sex Characteristics
/
Amenorrhea
/
Gonadotropins
/
Hypogonadism
Type of study:
Observational study
Limits:
Adolescent
/
Female
/
Humans
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2019
Type:
Article
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