Association between Plasma Vitamin D Level and Brachial-ankle Pulse Wave Velocity / 대한골다공증학회지
Journal of Korean Society of Osteoporosis
;
: 32-38, 2012.
Article
in Korean
| WPRIM
| ID: wpr-760781
ABSTRACT
OBJECTIVES:
Low 25 (OH) vitamin D increases the risk of cardiovascular disease and mortality. Pulse wave velocity (PWV), which is related with arterial stiffness, can be used evaluate the severity of systemic atherosclerosis. Brachial-ankle PWV (baPWV) is affected by sex, age, systolic blood pressure, body mass index, and waist circumference. We evaluated determinants of PWV in Korean adults andits associationwith the plasma vitamin D level and arterial stiffness. MATERIALS ANDMETHODS:
The study was conducted on 178 adults (>age of 20) who visited thehealth promotion center. We investigated medical history, medication, smoking and alcohol use by means of questionnaire. We measuredblood pressure, pulse rate, fasting glucose, fasting insulin, lipid profile, hs-CRP, plasma 25 (OH) vitamin D level, and baPWV. We then analyzed retrospectively the relationship between baPWV and various risk factors.RESULTS:
The mean ages in 97 males and 81 females were 47.9+/-13 and 43.6+/-11.4 years, respectively. baPWV is correlated with age, BMI, waist, blood pressure, fasting glucose, HTN, DM, total cholesterol, triglyceride, hs-CRP, and 25 (OH) vitamin D. We found out that age (beta=7.49, P<0.001), BMI (beta=-10.05, P=0.023), SBP (beta=7.69, P<0.001), TG (beta=111.41, P=0.039), and fasting glucose (beta=1.447, P=0.561) were independent predictors of baPWVafter performing multiple linear regression analysis.CONCLUSIONS:
baPWV was affected by age, SBP, BMI, TG, and fasting glucose. Deficiency of 25 (OH) vitamin Dwas not associated with baPWV after adjusting the risk factors of cardiovascular diseases in this study group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Smoke
/
Vitamin D
/
Vitamins
/
Blood Pressure
/
Cardiovascular Diseases
/
Smoking
/
Body Mass Index
/
Linear Models
/
Cholesterol
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Society of Osteoporosis
Year:
2012
Type:
Article
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