Tissue Transglutaminase Antibody and Its Association with Duodenal Biopsy in Diagnosis of Pediatric Celiac Disease / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 350-357, 2019.
Article
in English
| WPRIM
| ID: wpr-760862
ABSTRACT
PURPOSE:
This study aimed to evaluate a possible association between the anti-tissue transglutaminase antibody (anti-tTG) titer and stage of duodenal mucosal damage and assess a possible cut-off value of anti-tTG at which celiac disease (CD) may be diagnosed in children in conjunction with clinical judgment.METHODS:
This observational study was conducted at a gastroenterology clinic in a tertiary hospital from April 2012 to May 2013. Seventy children between 6-months and 18-years-old with suspected CD underwent celiac serology and duodenal biopsy. Statistical analyses were done using SPSS 16. Diagnostic test values were determined for comparing the anti-tTG titer with duodenal biopsy. An analysis of variance and Tukey-Kramer tests were performed for comparing the means between groups. A receiver operating characteristics curve was plotted to determine various cut-off values of anti-tTG.RESULTS:
The mean antibody titer increased with severity of Marsh staging (p<0.001). An immunoglobulin (Ig) A-tTG value at 115 AU/mL had 76% sensitivity and 100% specificity with a 100% positive predictive value (PPV) and 17% negative predictive value (NPV) for diagnosis of CD (p<0.001, 95% confidence interval [CI], 0.75–1).CONCLUSION:
There is an association between the anti-tTG titer and stage of duodenal mucosal injury in children with CD. An anti-tTG value of 115 AU/mL (6.4 times the upper normal limit) had 76% sensitivity, 100% specificity, with a 100% PPV, and 17% NPV for diagnosing CD (95% CI, 0.75–1). This cut-off may be used in combination with clinical judgment to diagnose CD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Immunoglobulins
/
Celiac Disease
/
ROC Curve
/
Sensitivity and Specificity
/
Diagnosis
/
Diagnostic Tests, Routine
/
Duodenitis
/
Wetlands
/
Tertiary Care Centers
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2019
Type:
Article
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