Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age Children with Gastroesophageal Reflux Symptoms? / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 511-517, 2019.
Article
in English
| WPRIM
| ID: wpr-760891
ABSTRACT
PURPOSE:
On the basis of evidence, we aimed to reevaluate the necessity of the empirical proton pump inhibitor (PPI) trial for children with suspected gastroesophageal reflux disease (GERD).METHODS:
We analyzed the frequency of GERD in 85 school-age children with gastroesophageal reflux (GER) symptoms, who received 24-hour esophageal pH monitoring and/or upper endoscopy. According to the reflux index (RI), the children were classified into normal (RI <5%), intermediate (5%≤ RI <10%), or abnormal (RI ≥10%) groups.RESULTS:
Fifty six were female and 29 were male. Their mean age was 12.6±0.5 (±standard deviation) years (range 6.8–18.6). The RI analysis showed that the normal group included 76 patients (89.4%), the intermediate group included 6 patients (7.1%), and the abnormal group included 3 patients (3.5%). The DeMeester score was 5.93±4.65, 14.68±7.86 and 40.37±12.96 for the normal, intermediate and abnormal group, respectively (p=0.001). The longest reflux time was 5.56±6.00 minutes, 9.53±7.84 minutes, and 19.46±8.35 minutes in the normal, intermediate, and abnormal group, respectively (p=0.031). Endoscopic findings showed reflux esophagitis in 7 patients. On the basis of the Los Angeles Classification of Esophagitis, 5 of these patients were included in group A, 1 patient, in group B and 1 patient, in group C.CONCLUSION:
The incidence of GERD was very low in school-age children with GER symptoms. Therefore, injudicious diagnostic PPI trials would be postponed until the actual prevalence of GERD is verified in future prospective studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protons
/
Esophagitis, Peptic
/
Gastroesophageal Reflux
/
Incidence
/
Prevalence
/
Prospective Studies
/
Classification
/
Proton Pumps
/
Endoscopy
/
Esophagitis
Type of study:
Diagnostic study
/
Incidence study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2019
Type:
Article
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