Your browser doesn't support javascript.
loading
An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment
Psychiatry Investigation ; : 759-765, 2019.
Article in English | WPRIM | ID: wpr-760904
ABSTRACT

OBJECTIVE:

Cyanidin-3-glucoside (C3G), is a component of anthocyanin, have been considered to positively influence cognition and be beneficial for the prevention and treatment of dementia. We aimed to assess the safety and efficacy of cyanidin-3-glucoside-rich Oryza sativa L. (black rice) extract on cognitive function.

METHODS:

A 12-weeks double-blind randomized, placebo controlled trial assessed safety and cognitive outcomes in participants with subjective memory impairment (n=48) following consumption of 6 black rice extract capsules or a placebo. Cognitive function was assessed using the ADAS-cog and the CERAD-K. Subjective memory impairment also assessed. Safety was assessed by hematologic blood test, urine analysis, and participant reports of adverse events.

RESULTS:

There was significant improvement on subjective memory in intervention group. There was no statistically significant difference in objective cognitive outcomes following 12 weeks of consuming black rice extract. ADAS-cog scores, however, trended toward improvement in the intervention group compared to the placebo group. There was no adverse event.

CONCLUSION:

Although significant improvement in objective cognitive function was not proved, we found that C3G-rich Oryza sativa L. extract improves subjective memory in this study. Therefore the results may be informative of the possible effectiveness of the C3G-rich Oryza sativa L. on cognitive function.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oryza / Capsules / Cognition / Dementia / Hematologic Tests / Memory / Anthocyanins Type of study: Controlled clinical trial Limits: Adult / Humans Language: English Journal: Psychiatry Investigation Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oryza / Capsules / Cognition / Dementia / Hematologic Tests / Memory / Anthocyanins Type of study: Controlled clinical trial Limits: Adult / Humans Language: English Journal: Psychiatry Investigation Year: 2019 Type: Article