Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population
Psychiatry Investigation
;
: 379-385, 2019.
Article
in English
| WPRIM
| ID: wpr-760935
ABSTRACT
OBJECTIVE:
To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population.METHODS:
We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal cortex, and examined the expression of the genes in ASD cases and healthy controls using the GSE38322 data set. Following, we performed a case-control study in a Chinese population.RESULTS:
The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of human brain and contribute to the risk of ASD. Later genetic analysis in the Chinese population showed that the GRIK2 rs6922753 for the T allele, TC genotype and dominant model played a significant protective role in ASD susceptibility (respectively OR=0.840, p=0.023; OR=0.802, p=0.038; OR=0.791, p=0.020). The NLGN1 rs9855544 for the G allele and GG genotype played a significant protective role in ASD susceptibility (respectively OR=0.844, p=0.019; OR=0.717, p=0.022). After adjusting p values, the statistical significance was lost (p>0.05).CONCLUSION:
Our results suggested that GRIK2 rs6922753 and NLGN1 rs9855544 might not confer susceptibility to ASD in the Chinese population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autistic Disorder
/
Brain
/
Case-Control Studies
/
Prefrontal Cortex
/
Glutamic Acid
/
Asian People
/
Alleles
/
Receptors, Ionotropic Glutamate
/
Dataset
/
Autism Spectrum Disorder
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2019
Type:
Article
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