The use of tissue fiducial markers in improving the accuracy of post-prostatectomy radiotherapy
Radiation Oncology Journal
;
: 43-50, 2019.
Article
in English
| WPRIM
| ID: wpr-760990
ABSTRACT
PURPOSE:
The aim of this retrospective study was to investigate the use of a radiopaque tissue fiducial marker (TFM) in the treatment of prostate cancer patients who undergo post-prostatectomy radiotherapy (PPRT). TFM safety, its role and benefit in quantifying the set-up uncertainties in patients undergoing PPRT image-guided radiotherapy were assessed. MATERIALS ANDMETHODS:
A total of 45 consecutive PPRT patients underwent transperineal implantation of TFM at the level of vesicourethral anastomosis in the retrovesical tissue prior to intensity-modulated radiotherapy. Prostate bed motion was calculated by measuring the position of the TFM relative to the pelvic bony anatomy on daily cone-beam computed tomography. The stability and visibility of the TFM were assessed in the initial 10 patients.RESULTS:
No postoperative complications were recorded. A total of 3,500 images were analysed. The calculated prostate bed motion for bony landmark matching relative to TFM were 2.25 mm in the left-right, 5.89 mm in the superior-inferior, and 6.59 mm in the anterior-posterior directions. A significant 36% reduction in the mean volume of rectum receiving 70 Gy (rV₇₀) was achieved for a uniform planning target volume (PTV) margin of 7 mm compared with the Australian and New Zealand Faculty of Radiation Oncology Genito-Urinary Group recommended PTV margin of 10 mm.CONCLUSION:
The use of TFM was safe and can potentially eliminate set-up errors associated with bony landmark matching, thereby allowing for tighter PTV margins and a consequent favourable reduction in dose delivered to the bladder and rectum, with potential improvements in toxicities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Complications
/
Prostate
/
Prostatectomy
/
Prostatic Neoplasms
/
Radiotherapy
/
Rectum
/
Urinary Bladder
/
Retrospective Studies
/
Clothing
/
Radiation Oncology
Type of study:
Observational study
Limits:
Humans
Country/Region as subject:
Oceania
Language:
English
Journal:
Radiation Oncology Journal
Year:
2019
Type:
Article
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