Measuring the Behavioral Parameters of Mouse Following Unilateral Labyrinthectomy in Round Free Field Using an Infrared Lamp and a Simple Webcam Camera / 대한평형의학회지
Journal of the Korean Balance Society
;
: 12-18, 2011.
Article
in Korean
| WPRIM
| ID: wpr-761082
ABSTRACT
BACKGROUND AND OBJECTIVES:
In this research, movements of mouse after labyrinthectomy were analyzed to determine the degree of vestibular dysfunction and compensation. MATERIALS ANDMETHODS:
By using an infrared lamp, mouse movements were recorded for 100 seconds in a dark room. The experimental area was manufactured as a circular space with a diameter of 60 cm. The movements of five mice labyrinthectomized on right side were observed and recorded at 3 hours, 9 hours and 120 hours after the operation, and also the ten mice of control group.RESULTS:
The differences between the total moving distances and the rotating angle from the origin that set the center of round field between groups were analyzed with pictures of 1 frame per second. It is concluded that all 4 groups show significant differences between its mean rotation angle and total moving distances statistically. At 9 hours after right labyrinthectomy, mice tended to turn clockwise; but at 120 hours, there was no significant difference between clockwise and counter-clockwise rotation.CONCLUSION:
Measuring the movement of mouse in round free field can be the proper method to determine the degree of vestibular dysfunction and vestibular compensation. This test was time-saving and cost-effective method.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Compensation and Redress
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Balance Society
Year:
2011
Type:
Article
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