Your browser doesn't support javascript.
loading
Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats / 대한평형의학회지
Journal of the Korean Balance Society ; : 131-137, 2012.
Article in English | WPRIM | ID: wpr-761125
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is mediated by the excitatory neurotransmitter, glutamate. In this study, the signaling pathway of glutamate in the vestibular nuclei following acute hypotension was investigated. MATERIALS AND

METHODS:

Expression of metabotropic glutamate receptors (mGluRs) was measured by Western blotting in the medial vestibular nucleus following acute hypotension in rats.

RESULTS:

Expression of pGluR1 Ser831, a subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, peaked at 30 minutes after acute hypotension insult, and expression of pNR2B, a subtype of N-methyl-D-aspartate (NMDA) receptors, peaked at 2 hours after acute hypotension insult. Acute hypotension induced expression of Homer1a and group I mGluR in the medial vestibular nucleus. Expression of mGluR1 and mGluR5 peaked at 6 hours following acute hypotension insults.

CONCLUSION:

These results suggest that afferent signals from the peripheral vestibular receptors, resulting from acute hypotension insult, are transmitted through group I mGluRs as well as AMPA and NMDA receptors in the vestibular system.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphotransferases / Vestibular Nuclei / Blotting, Western / N-Methylaspartate / Receptors, N-Methyl-D-Aspartate / Receptors, Metabotropic Glutamate / Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Neurotransmitter Agents / Glutamic Acid / Hypotension Limits: Animals Language: English Journal: Journal of the Korean Balance Society Year: 2012 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphotransferases / Vestibular Nuclei / Blotting, Western / N-Methylaspartate / Receptors, N-Methyl-D-Aspartate / Receptors, Metabotropic Glutamate / Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Neurotransmitter Agents / Glutamic Acid / Hypotension Limits: Animals Language: English Journal: Journal of the Korean Balance Society Year: 2012 Type: Article