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Neuromyelitis Optica Spectrum Disorder Presented with Upbeat Nystagmus and Intractable Vomiting / 대한평형의학회지
Journal of the Korean Balance Society ; : 50-53, 2019.
Article in Korean | WPRIM | ID: wpr-761293
ABSTRACT
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating autoimmune disease of central nervous system characterized by relapsing attacks that target the optic nerves and spinal cord, as well as aquaporin-4 (AQP4) enriched periventricular brain regions. The area postrema (AP), located in the dorsal medulla, is the chemosensitive vomiting center and has high AQP-4 expression. The AP syndrome with unexplained hiccups, nausea, and vomiting is one of the core clinical characteristics in the NMOSD and maybe the first presenting symptom. We experienced a 25-year-old woman presented with intractable vomiting, dizziness and oscillopsia. Upbeat nystagmus detected on the bedside examination led to comprehensive neurological workups including magnetic resonance imaging, and she was diagnosed as the AP syndrome. Ten months later, she experienced a recurrence as a longitudinally extensive transverse myelitis and the diagnosis was finally compatible with NMOSD without AQP4-IgG. NMOSD, especially the AP syndrome, should be considered in any dizzy patient with intractable vomiting, and detailed neuro-otologic and neuro-ophthalmologic examinations are warranted for the correct diagnosis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Optic Nerve / Recurrence / Autoimmune Diseases / Spinal Cord / Vomiting / Brain / Magnetic Resonance Imaging / Central Nervous System / Nystagmus, Pathologic / Neuromyelitis Optica Type of study: Diagnostic study Limits: Adult / Female / Humans Language: Korean Journal: Journal of the Korean Balance Society Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Optic Nerve / Recurrence / Autoimmune Diseases / Spinal Cord / Vomiting / Brain / Magnetic Resonance Imaging / Central Nervous System / Nystagmus, Pathologic / Neuromyelitis Optica Type of study: Diagnostic study Limits: Adult / Female / Humans Language: Korean Journal: Journal of the Korean Balance Society Year: 2019 Type: Article