The Potential Cardioprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors / 임상당뇨병
Journal of Korean Diabetes
; : 81-86, 2019.
Article
in Ko
| WPRIM
| ID: wpr-761480
Responsible library:
WPRO
ABSTRACT
The potential mechanism by which sodium-glucose cotransporter 2 (SGLT2) inhibitors prevent cardiovascular disease (CVD) is being widely investigated. Improved insulin resistance, along with decreased body fat mass associated with SGLT2 inhibitor treatment is consistent with previously well-established factors contributing to the prevention of CVD. These factors are responsible for reduction of oxidative stress as well as improvement of systemic inflammation. Because heart failure was one of the most dramatically improved cardiovascular events in various clinical trials and because SGLT2 inhibitors promote osmotic diuresis and natriuresis, hemodynamic changes are considered as a critical mechanism responsible for the cardioprotective effect of SGLT2 inhibitors. Restored tubuloglomerular feedback by SGLT2 inhibitors might play a role in renoprotection, which in turn, leads to fewer CVDs. Finally, blood ketone body increments in response to SGLT2 inhibition might act as a “super-fuel” for salvaging the failing diabetic heart.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Insulin Resistance
/
Cardiovascular Diseases
/
Adipose Tissue
/
Oxidative Stress
/
Diabetes Mellitus
/
Diuresis
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Sodium-Glucose Transport Proteins
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Heart
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Heart Failure
/
Hemodynamics
Language:
Ko
Journal:
Journal of Korean Diabetes
Year:
2019
Type:
Article