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Nodular Gastritis as a Precursor Lesion of Atrophic and Metaplastic Gastritis / 대한소화기병학회잡지
Korean Journal of Gastroenterology ; : 332-340, 2019.
Article in Korean | WPRIM | ID: wpr-761515
ABSTRACT
BACKGROUND/

AIMS:

Chronic atrophic gastritis (CAG) and metaplastic gastritis (MG) are precancerous conditions of Helicobacter pylori (H. pylori)-related gastric cancer. This study aimed to identify the characteristics of nodular gastritis (NG) showing CAG or MG after nodule regression.

METHODS:

H. pylori-infected patients with NG were included after upper gastrointestinal endoscopy. Patients were excluded if their latest endoscopy had been performed ≤36 months after the initial diagnosis of NG. Small-granular-type NG was defined as the condition with 1–2 mm regular subepithelial nodules. Large-nodular-type NG was defined as those with 3–4 mm, irregular subepithelial nodules. The endoscopic findings after nodule regression were recorded.

RESULTS:

Among the 97 H. pylori-infected patients with NG, 61 showed nodule regression after a mean follow-up of 73.0±22.0 months. After nodule regression, 16 patients showed a salt-and-pepper appearance and/or transparent submucosal vessels, indicating CAG. Twenty-nine patients showed diffuse irregular elevations and/or whitish plaques, indicating MG. Sixteen patients with other endoscopic findings (14 normal, one erosive gastritis, and one chronic superficial gastritis) showed a higher proportion of H. pylori eradication (12/16, 75.0%) than those in the CAG group (5/16, 31.3%) and MG group (6/29, 20.7%; p=0.001). Patients with small-granular-type NG tended to progress toward CAG (14/27, 51.9%), whereas those with large-nodular-type NG tended to progress toward MG (25/34, 73.5%; p<0.001).

CONCLUSIONS:

In patients with a persistent H. pylori infection, NG tended to progress to CAG or MG when the nodules regressed. Small-granular-type NG tended to progress to CAG, whereas large-nodular-type NG tended to progress to MG.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Precancerous Conditions / Atrophy / Stomach Neoplasms / Follow-Up Studies / Endoscopy, Gastrointestinal / Helicobacter pylori / Diagnosis / Endoscopy / Gastritis / Gastritis, Atrophic Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Gastroenterology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Precancerous Conditions / Atrophy / Stomach Neoplasms / Follow-Up Studies / Endoscopy, Gastrointestinal / Helicobacter pylori / Diagnosis / Endoscopy / Gastritis / Gastritis, Atrophic Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Gastroenterology Year: 2019 Type: Article