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Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study / 대한소화기병학회잡지
Korean Journal of Gastroenterology ; : 17-29, 2019.
Article in English | WPRIM | ID: wpr-761527
ABSTRACT
BACKGROUND/

AIMS:

The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps.

METHODS:

Subjects with multiple gastric polyps (at least three) during endoscopy were enrolled prospectively. They were assigned to a fundic gland polyp (FGP) group and hyperplastic polyp (HP) group based on a histological classification of gastric polyps. Helicobacter pylori (H. pylori) was confirmed by its histology. Serum gastrin was measured using the radioimmunoassay method. A questionnaire was taken regarding the intake of proton pump inhibitor and nonsteroidal anti-inflammatory drugs, alcohol, smoking history, and diet.

RESULTS:

Among the 60 subjects enrolled from 2015 to 2018 at Seoul National University Bungdang Hospital, 47 and 13 subjects were assigned to the FGP and HP groups, respectively. The H. pylori infection rate was 12.8% in the FGP group, which is lower than that in the HP group (69.2%, p<0.001). The gastrin level was higher in the HP group (194.7 pg/dL, range 50.6–387.8 pg/dL) than in the FGP group (57.4 pg/dL, range 24.8–79.0 pg/dL) (p=0.007). Histologically, neutrophil infiltration in the antrum and body of the stomach were higher in the HP group than in the FGP group (p=0.022 and p=0.030, respectively). In contrast, monocyte infiltration in the antrum and body of the stomach were higher in the FGP group than in the HP group (p=0.018 and p<0.001, respectively).

CONCLUSIONS:

HPs arise from inflammation caused by H. pylori. On the other hand, the FGP was not associated with H. pylori or environmental factors.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Polyps / Smoke / Stomach / Gastrins / Radioimmunoassay / Monocytes / Smoking / Prospective Studies / Risk Factors / Cohort Studies Type of study: Etiology study / Incidence study / Observational study / Risk factors Country/Region as subject: Asia Language: English Journal: Korean Journal of Gastroenterology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polyps / Smoke / Stomach / Gastrins / Radioimmunoassay / Monocytes / Smoking / Prospective Studies / Risk Factors / Cohort Studies Type of study: Etiology study / Incidence study / Observational study / Risk factors Country/Region as subject: Asia Language: English Journal: Korean Journal of Gastroenterology Year: 2019 Type: Article