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Pancreatitis, Panniculitis, and Polyarthritis Syndrome Simulating Cellulitis and Gouty Arthritis / 대한소화기병학회잡지
Korean Journal of Gastroenterology ; : 175-182, 2019.
Article in English | WPRIM | ID: wpr-761542
ABSTRACT
Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare but critical disease with a high mortality rate. The diagnostic dilemma of PPP syndrome is the fact that symptoms occur unexpectedly. A 48-year-old man presented with fever and painful swelling of the left foot that was initially mistaken for cellulitis and gouty arthritis. The diagnosis of PPP syndrome was made based on the abdominal CT findings and elevated pancreatic enzyme levels, lobular panniculitis with ghost cells on a skin biopsy, and polyarthritis on a bone scan. The pancreatitis and panniculitis disappeared spontaneously over time, but the polyarthritis followed its own course despite the use of anti-inflammatory agents. In addition to this case, 30 cases of PPP syndrome in the English literature were reviewed. Most of the patients had initial symptoms other than abdominal pain, leading to misdiagnosis. About one-third of them were finally diagnosed with a pancreatic tumor, of which pancreatic acinar cell carcinoma was the most dominant. They showed a mortality rate of 32.3%, associated mainly with the pancreatic malignancy. Therefore, PPP syndrome should be considered when cutaneous or osteoarticular manifestations occur in patients with pancreatitis. Active investigation and continued observations are needed for patients suspected of PPP syndrome.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatic Neoplasms / Pancreatitis / Arthritis / Skin / Biopsy / Arthritis, Gouty / Panniculitis / Tomography, X-Ray Computed / Abdominal Pain / Cellulitis Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Korean Journal of Gastroenterology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatic Neoplasms / Pancreatitis / Arthritis / Skin / Biopsy / Arthritis, Gouty / Panniculitis / Tomography, X-Ray Computed / Abdominal Pain / Cellulitis Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Korean Journal of Gastroenterology Year: 2019 Type: Article