Safety of Anti-Obesity Drugs Approved for Long-Term Use
Korean Journal of Obesity
;
: 17-27, 2015.
Article
in Korean
| WPRIM
| ID: wpr-761605
ABSTRACT
Because of the widespread use of ant-obesity medications, bariatricians need to be aware not only of common adverse events but also uncommon serious events in the pharmacotherapy of obesity. Safety and tolerability must be considered in selecting the drug, titrating the dosage, and monitoring patients. In Korea, orlistat and lorcaserine are the two anti-obesity drugs that can be used for long-term treatment, and in the US, liraglutide, phentermine/topiramate, and naltrexone/bupropion have been recently approved. In general, all of these drugs have very good safety and tolerability profiles. Common adverse events of these drugs are well understood, and they can be coped with or prevented by adjusting the dosage properly. In addition, patients can recover from serious events by stopping the medication. However, there are other serious side effects that need to be monitored for. These include liver injury, acute kidney injury, and pancreatitis for orlistat; valvulopathy for lorcaserine; thyroid C-cell pathology and pancreatitis for liraglutide; metabolic acidosis, urolithiasis, acute angle closure glaucoma, and teratogenic effects for phentermine/topiramate; and severe nausea and heart disease for naltrexone/bupropion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Pathology
/
Thyroid Gland
/
Acidosis
/
Glaucoma, Angle-Closure
/
Anti-Obesity Agents
/
Drug Therapy
/
Urolithiasis
/
Acute Kidney Injury
/
Liraglutide
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Obesity
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS