Clinical Features and Prognosis of Spontaneous Bacterial Peritonitis in Korean Patients with Liver Cirrhosis: A Multicenter Retrospective Study
Gut and Liver
;
: 197-204, 2009.
Article
in English
| WPRIM
| ID: wpr-76192
ABSTRACT
BACKGROUND/AIMS:
Although early recognition and treatment with effective antibiotics have lead to improvements in the prognosis of patients with spontaneous bacterial peritonitis (SBP), it remains to be a serious complication in cirrhotic patients. This study was designed to evaluate the clinical manifestations and prognosis of patients with liver cirrhosis and SBP in Korea.METHODS:
This was a multicenter retrospective study examining 157 episodes of SBP in 145 patients with cirrhosis. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of >250 cells/mm3 in the absence of data compatible with secondary peritonitis.RESULTS:
The mean age of the cohort was 56 years, and 121 (77%) of the 157 episodes of SBP occurred in men. Microorganisms were isolated in 66 episodes (42%) Gram-negative bacteria in 54 (81.8%), Gram-positive in 11 (16.7%), and Candida in 1. Isolated Gram-negative organisms were resistant to third-generation cephalosporin in 6 cases (17%), to ciprofloxacin in 11 (20.8%), and to penicillin in 33 (62.3%). The treatment failure and in-hospital mortality rates were 12.1% and 21%, respectively. A high Model of End-Stage Liver Disease (MELD) score, SBP caused by extended-spectrum beta-lactamase-producing organisms, and hepatocellular carcinoma were independent prognostic factors of high in-hospital mortality.CONCLUSIONS:
SBP remains to be a serious complication with high in-hospital mortality, especially in patients with a high MELD score.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillins
/
Peritonitis
/
Prognosis
/
Fibrosis
/
Candida
/
Ascitic Fluid
/
Ciprofloxacin
/
Cell Count
/
Retrospective Studies
/
Cohort Studies
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Gut and Liver
Year:
2009
Type:
Article
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