Near-Infrared Contrast Agents for Bone-Targeted Imaging
Tissue Engineering and Regenerative Medicine
;
(6): 443-450, 2019.
Article
in English
| WPRIM
| ID: wpr-761927
ABSTRACT
BACKGROUND:
For the bone-specific imaging, a structure-inherent targeting of bone tissue recently has been reported a new strategy based on incorporation of targeting moieties into the chemical structure of near-infrared (NIR) contrast agents, while conventional methods require covalent conjugation of bone-targeting ligands to NIR contrast agents. This will be a new approach for bone-targeted imaging by using the bifunctional NIR contrast agents.METHODS:
The goal of this review is to provide an overview of the recent advances in optical imaging of bone tissue, highlighting the structure-inherent targeting by developing NIR contrast agents without the need for a bone-targeting ligand such as bisphosphonates.RESULTS:
A series of iminodiacetated and phosphonated NIR contrast agents for the structure-inherent targeting of bone tissue showed excellent bone-targeting ability in vivo without non-specific binding. Additionally, the phosphonated NIR contrast agents could be useful in the diagnosis of bone metastasis.CONCLUSION:
By developing bone-targeted NIR contrast agents, optical imaging of bone tissue makes it very attractive for preclinical studies of bone growth or real-time fluorescence guided surgery resulting in high potential to shift the clinical paradigms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone and Bones
/
Bone Development
/
Contrast Media
/
Surgery, Computer-Assisted
/
Diagnosis
/
Diphosphonates
/
Optical Imaging
/
Fluorescence
/
Ligands
/
Neoplasm Metastasis
Type of study:
Diagnostic study
Language:
English
Journal:
Tissue Engineering and Regenerative Medicine
Year:
2019
Type:
Article
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