Antiepileptic drug-induced severe cutaneous adverse reactions and HLA alleles: A report of five cases with lymphocyte activation test
Translational and Clinical Pharmacology
;
: 64-68, 2019.
Article
in English
| WPRIM
| ID: wpr-761933
ABSTRACT
Antiepileptic drugs (AEDs) can induce severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We performed HLA genotyping and lymphocyte activation tests (LATs) for five AED-induced SCAR patients (three males and two females; aged 40–66 years old). Three patients were treated with carbamazepine (CBZ) for pain control, one was treated with phenytoin (PHT) for seizure prevention, and one was treated with valproic acid (VPA) for seizure prevention. One patient was diagnosed with CBZ-induced DRESS syndrome and the remaining patients were diagnosed with SJS. All patients recovered from SCARs after stopping suspicious drugs and supportive care. LATs were conducted to confirm the culprit drug responsible for inducing SCARs; and LAT results were positive for the suspected culprit drugs, in all except in one case. HLA-A,
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenytoin
/
Seizures
/
Long-Acting Thyroid Stimulator
/
Carbamazepine
/
Lymphocyte Activation
/
Lymphocytes
/
HLA-A Antigens
/
Valproic Acid
/
Cicatrix
/
Stevens-Johnson Syndrome
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2019
Type:
Article
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